Saloni Aswani was born in Ulhasnagar, Maharashtra, India. She belongs to a Sindhi family and her actual name is Vandana Aswani. Her mother Naina Aswani wanted her to become an actress and her father was a Customs Officer. She stayed with her family at the CGS quarters in Mumbai. Saloni is a graduate in psychology from SNDT, Mumbai. Later, she joined Ashok Kumar's Acting School, Mumbai. She was also a part of a theater named Kala Sansad.
Sawaan Kumar Tak, the director of her debut film, changed her name from Vandana to Saloni. The actress has done various advertisements for brands like Vaseline, Lifebuoy, Parachute Oil, Moove, Chic shampoo, Three Roses tea, Meera soaps, and more. Saloni is good at copying Sridevi and has presented it in many dramas.